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The genetic testing platform detecting and measuring disease.
BillionToOne has developed a DNA molecular counter that increases the cell-free DNA diagnostics resolution by over 1,000 fold, which unlocks transformative improvements in prenatal screening and liquid biopsy for cancers. Unity Screen, BillionToOne's commercially available non-invasive prenatal test (NIPT), is the only NIPT that can assess fetal risk for both recessive conditions and aneuploidies from maternal blood. UNITY Screen continues to grow exponentially and is on its path to becoming the next standard-of-care, with an increasing number of publications showing its accuracy and advantages over other screening methods. We have also recently used our molecular counting technology to develop liquid biopsy tests, which have the potential to completely transform oncology care.
BillionToOne offers a genetic testing platform that directly measures disease-related DNA fragments using single-molecule, cfDNA-based assays for prenatal and oncology applications. Their tests aim to provide actionable insights from a single blood draw, spanning non-invasive prenatal testing and liquid biopsy for cancer. They emphasize single-molecule quantification to advance prenatal screening, liquid biopsy, and beyond.
The company uses Quantitative Counting Templates (QCTs) to power its smNGS platform, enabling direct measurement of sparse disease-causing DNA fragments at the single base-pair level from cell-free DNA. Its products include Prenatal Unity Complete (a non-invasive prenatal test using cfDNA to assess fetal risk for recessive conditions and aneuploidy from a single maternal blood draw at 9+ weeks) and Oncology Northstar Select and Northstar Response (pan-cancer liquid biopsy tests that guide therapy selection and enable real-time treatment response monitoring).
Who it’s for: Expectant mothers and families concerned with prenatal genetic risk; oncology patients requiring liquid biopsy-based monitoring and treatment guidance.
Active product launches and multiple press releases; ongoing hiring and career opportunities; public company milestones and investor communications
How BillionToOne’s homepage introduced itself over the years — each line is the page title the web actually saw, linked to that moment’s archived capture.

Cancer tests based on whole genome and transcriptome data.

Our tests help eradicate cancer by telling doctors whether they got…