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A platform to make artificial viruses as cancer therapeutics.
Humane Genomics has developed a platform to engineer cancer killing viruses. We have taken a first principles approach to design and make oncolytic viral therapies. Using a highly lytic RNA virus engineered with "2 factor authentication" (using selective infection and selective replication) they have an on-target to off-target kill ratio > 1000. We are working on our first indication, pediatric liver cancer (hepatoblastoma), with our partners at Texas Children's Hospital, who are world leading experts. We have in vivo (mouse) data showing safety and currently developing efficacy data and are showing 50% reduction in tumor volume.
Humane Genomics develops cancer therapies by engineering cancer-killing RNA viruses using a synthetic biology platform. They aim to create precision-designed oncolytic viral therapies that selectively target and destroy cancer cells.
The company engineers RNA viruses for cancer therapeutics and uses controls such as aptazymes to regulate viral replication, enhancing selectivity. They are pursuing manufacturing partnerships (e.g., cGMP manufacturing) for their lead oncolytic virus candidate and emphasize a platform approach to design viruses that preferentially replicate in cancerous tissue.
Who it’s for: Biotech/pharma researchers and developers, oncology researchers, biotech companies seeking experimental cancer therapeutics, research institutions exploring oncolytic virology.
partnership with Genezen for cGMP manufacturing; relocation to innovation spaces; ongoing updates on core tech and platform
Building a highly efficient platform to make artificial viruses as cancer therapeutics. Serial entrepreneur. Founder and former CEO of Shapeways. Have built and led software and product teams for 3 companies. Love to code, grow plants, brew beer, cook Asian food, and more. BSc Applied Physics.
Building a platform to engineer viruses as precision cancer therapies. Previous: Biotech, Columbia & Public Health, Tulane. Interested in sailing and pickleball.
Unleashing the potential of DNA and RNA based therapies using AI
Cell-specific genetic medicines
