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Thesis

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Automate AI research

Fall 2025Founded 20252 peopleSan Francisco, CA, USA

About

We are accelerating AI research and development. Our aim is to help researchers uncover the next AlphaFold or build the next Transformer, faster, more systematically, and at scale. We treat discovery not as a matter of luck, but as an intelligent search problem. By giving researchers access to an autonomous AI research lab, Thesis lets you build powerful machine learning models for anything imaginable. Every major breakthrough in AI over the next decade will be made on Thesis.

Founders Β· 2

Sergio Charles
Sergio CharlesCo-Founder & CEO
GoogleNvidiaStanford

Thesis will automate AI research. Maximally truth-seeking. Prev: AI R&D at Google X, Nvidia and Stanford's AI Lab, working with Andrew Ng and Chelsea Finn. B.S. Math & CS, M.S. Stats Stanford

Luigi Charles
Luigi CharlesFounder
Columbia

Betting the farm that AI will become meaningful in the discovery of new science. Second time founder. Previously scaled stablecoin payments infrastructure from zero to billions. Columbia CS & Math.

Launch

Launched on Y Combinator Β· Nov 2025
View launch post β†—

Making it possible for researchers anywhere to discover the next Transformer or invent the next AlphaFold.

Thesis is an applied AI lab that accelerates AI discovery, enabling researchers worldwide to discover new models like Transformers or innovations such as AlphaFold. It aims to make state-of-the-art AI discovery 10x faster and cheaper, focusing on rapid experimentation and autonomous model training, with results on OpenAI’s MLE-Bench and a team with backgrounds in AI research and fintech.

Formerly β€œThesis Labs”

B2BAI

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